Tell your doctor about all the prescription and over-the-counter medications you use. Brandweek also honors the Marketer of the Year in our highly-anticipated special report. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Avalide and you must continue taking it even if you are feeling avalide uten rx well. Study II compared the irbesartan-hydrochlorothiazide combinations of 75 12. Analysis of age, gender, and race subgroups of patients showed that men and women, and patients over and under 65 years of age, had generally similar responses. When administered during the second or third trimester of pregnancy, drugs that act directly on the renin-angiotensin system can cause fetal and neonatal morbidity and death. Hepatic Impairment Hydrochlorothiazide Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.